TSP-1 reduced C3 and C5 cleavage and formation of the membrane attack complex, attenuating complement-mediated injury in AAV models. Complement activation is a relevant driver in the pathomechanisms ...
Pore-forming toxins (PFTs) constitute a diverse class of proteins that permeabilise lipid bilayers, serving roles in bacterial virulence, immune defence and intercellular signalling. They encompass ...
Nanoparticles introduced into the bloodstream encounter the immune complement system, a proteolytic cascade that bridges innate surveillance and adaptive responses. Complement activation can occur via ...
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