In a recent study published in Nature Communications, researchers performed genome-wide copy number profiling of the androgen receptor (AR) on metastases from deceased prostate cancer patients. Study: ...

Various approaches have been developed to identify and quantitate copy-number variation. A new, high-resolution approach that already shows promise is digital PCR. As illustrated by many research ...

Changes in genomic copy number can also occur via whole-genome doubling (WGD) and chromothripsis. These evolutionary events may be rampant during tumor development and can transpire into the evolution ...

The evolution of the MUC7 gene, which encodes a saliva protein, was studied by scientists at the University at Buffalo. To capture the gene’s proline-, threonine-, and serine-rich tandem repeat copy ...

Association of Timely Comprehensive Genomic Profiling With Precision Oncology Treatment Use and Patient Outcomes in Advanced Non–Small-Cell Lung Cancer Somatic chromosomal alterations, particularly ...

Parents' Experiences With and Preferences for Receiving Information About Tumor Genomic Sequencing: Findings From a Qualitative Study and Implications for Practice For a 2-year overall survival end ...

We learn that we inherit two copies of every gene, one from each of our parents, but the story is a bit more complex. Some parts of the genome may be duplicated, or deleted, in some people. The number ...

MACHETE is a new CRISPR-based technique developed to study large-scale genetic deletions efficiently in laboratory models. MACHETE is a new CRISPR-based technique developed by researchers at the Sloan ...

“Such knowledge on physiological decline throughout pregnancy and the remarkable rejuvenation right after delivery will assist with revolutionizing our approach to treating the elderly.” “We ...

Early treatment in SMA provides benefits, but children with two SMN2 copies may still experience significant motor delays and disabilities. Infants with two SMN2 copies showed delayed motor milestones ...