Nature

Simultaneous single-cell sequencing of RNA and DNA at scale with DEFND-seq

Genetic information flows in one direction, from DNA to RNA to protein — this central dogma forms the foundation of molecular biology. With single-cell technology we can explore each step of this ...
Medical Xpress

RNA-seq outperforms DNA methods in detecting actionable cancer mutations

Among 103 samples with matched DNA sequencing, RNA-seq detected 93.3% of oncogenic variants. Variant allele frequencies between RNA-seq and DNA-seq showed strong correlations. Among tumors sequenced ...
Nature

RCANE: a deep learning algorithm for whole-genome pan-cancer somatic copy number aberration prediction using RNA-seq data

Somatic copy number aberrations (SCNAs) are a hallmark of cancer, involving large-scale genomic alterations that drive tumorigenesis and cancer progression by affecting gene dosage and altering the ...
Labroots

Simplifying the options for RNA-seq: A short guide to different methods

The answer depends on the questions you’re trying to answer, as well as the origin, quantity, and quality of your samples. In this article, we’ll briefly discuss several RNA-seq workflows, how they ...