Tousled-like kinases (TLKs) are conserved serine/threonine kinases that orchestrate chromatin dynamics during DNA replication and repair. These enzymes transiently associate with histone chaperones ...

DNA polymerase delta (Pol δ) is a central enzyme in eukaryotic genome duplication and maintenance, operating as a four-subunit holoenzyme composed of one catalytic subunit (POLD1) and three accessory ...

Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...

Tiny tweaks in DNA folding can have big effects. A study from Umeå University shows that even the most subtle changes in DNA's shape have an important influence on gene activity and energy production.

Researchers at the University of Minnesota Medical School have developed a new method called PARTAGE that provides a clearer picture of how the genome is regulated and disrupted in diseases like ...

A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified. A protein that is involved in determining which enzymes cut or unwind DNA ...

A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified in a new study. In a new paper published in Nature Communications, an ...

A blue-and-gray 3D representation of a strand of DNA with other strands floating in the background. Google has officially released its AlphaGenome machine learning model, which can predict the ...

CDT1 inhibits the helicase activity of the MCM complex, thereby suppressing nascent strand synthesis in DNA replication in cultured human cells. This action results in fork collapse and DNA damage, ...

A representative figure showing that HELQ-deficient cells fail to undergo normal fork slowing after MMC (a crosslinking agent) treatment, consistent with defective fork reversal. Every time a cell ...