The MCM helicase is broadly bound across the genome, and its phosphorylation is antagonistically regulated by the kinase DDK and the phosphatase RIF1–PP1. TRESLIN–MTBP recognises the phosphorylated ...

Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies, known as "sister chromatids," are held together by a ring-shaped protein ...

Faithful replication of the genome is essential for development, tissue homeostasis and prevention of malignancy. Key steps in eukaryotic DNA replication include the licensing of replication origins, ...

Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...

Weakened DNA repair is a feature of diseases that are associated with so-called “accelerated aging.” In a rare disease called Werner’s syndrome, for example, a single gene defect interferes with DNA ...

A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified. A protein that is involved in determining which enzymes cut or unwind DNA ...

Scientists uncovered DNA's double helix structure in 1953. James Watson and Francis Crick proposed the model. It explained ...

Mitochondrial DNA (mtDNA) exhibits remarkable variability across eukaryotic life, reflecting both historical evolutionary events and ongoing population dynamics. Typically a small circular molecule ...

For more than a century, heredity has been framed through the tidy logic of Mendel's pea plants: traits pass from parent to offspring by fixed genetic rules. But a new mouse study suggests that ...

The human genome has to be carefully organized so it will fit inside of the nuclei of cells, while also remaining accessible to the cellular machinery that works to express the right genes at the ...

Drs Ursula A. Matulonis and Joyce F. Liu discuss targeting DNA damage and repair and replication stress in endometrial cancer. Drs Ursula A. Matulonis and Panagiotis A. Konstantinopoulos discuss ...

Before the DNA revolution of the early 2000s, genealogy was a study dependent on records. Tracing a line of heritage could hit a dead end if documentation had gone missing or been destroyed. But as ...