Physicists introduce phase contrast to electron microscopy, delivering sharper images of our body's tiniest proteins

Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which ...
C&EN

A new, ultrabright laser powers a cryo-EM advance 15 years in the making

Fifteen years ago, physicists worked out a method to increase image contrast by hitting the electron imaging beam with an ...
Nature

Machine learning approach for recognition and morphological analysis of isolated astrocytes in phase contrast microscopy

Astrocytes are glycolytically active cells in the central nervous system playing a crucial role in various brain processes from homeostasis to neurotransmission. Astrocytes possess a complex branched ...
Nature

Use of phase plate cryo-EM reveals conformation diversity of therapeutic IgG with 50 kDa Fab fragment resolved below 6 Å

Antibodies, essential components of the immune system, are specialized immunoglobulin molecules designed to identify specific foreign substances, primarily proteins from pathogens such as viruses and ...