Highly reactive organometallic reagents, like organolithiums (molecules with a carbon–lithium bond) are essential reagents in organic synthesis because of their applications from polymer synthesis to ...

Total synthesis of natural products via cycloaddition reactions brings together strategic bond construction with the precision of pericyclic processes to assemble complex molecular frameworks from ...

Inspired by what human liver enzymes can do, chemists have developed a new set of copper-catalyzed organic synthesis reactions for building and modifying pharmaceuticals and other molecules. The new ...

Photochemical reactions harness the energy of light to drive the formation and manipulation of organic molecules. By accessing excited‐state intermediates, chemists can initiate bond‐forming processes ...

This new cerium-based catalyst interconverts between two oxidation states with distinct chemical properties, enabling two completely different reactions to occur in the same container. Most of the ...

Chemists from ETH Zurich have found a way to produce poorly soluble proteins by caging a uniquely reactive boron compound. This method opens up new possibilities for the synthesis of tailored protein ...

With artificial intelligence, scientists can design increasingly complex small molecule structures. Automation is critical for transforming these compounds from designs on a screen into actual ...

When Clay Bennett started his postdoctoral stint in 2005, he thought—“naively,” he admits—that he would spend just a couple of months preparing a few grams of an oligosaccharide before using the ...