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🚨 Low SHBG Is a Red Flag — Not a Goal ✅ Higher SHBG = lower risk of: • Type 2 diabetes • Coronary artery disease • Atherosclerosis And this isn’t just correlation — it’s causal. 🧪 Mendelian randomization studies (which use genetic proxies to eliminate confounders) show that people born with lower SHBG have higher risk of: • Metabolic syndrome • Ischemic heart disease • Coronary heart disease 📚 Key references: • Ding et al., NEJM 2009 → Low SHBG independently predicts diabetes • Perry et al.,
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🚨 Low SHBG Is a Red Flag — Not a Goal ✅ Higher SHBG = lower risk …
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